The 67th In Silico Megabank Research Seminar(December 11, 2015)

The 67th In Silico Megabank Research Seminar will be held on Friday, December 11.

This Time, we will be welcoming Dr. Kazuhiro Nakayama, Center for Molecular Medicine, Jichi Medical University as our lecturer, and he will be speaking on “Construction of Visceral Adipose Genome Bank and its Use”.

・Date/Time: December 11 (Friday) 5:00 pm‐6:30 pm
・Venue: Small Conference Room 2(3rd Floor), Tohoku Medical Megabank Building
・Title: Construction of Visceral Adipose Genome Bank and its Use
・Lecturer: Kazuhiro Nakayama(Center for Molecular Medicine, Jichi Medical University )

*This lecture is transferable as a class in the medical research-related lecture course.

・Abstract: Visceral adipose is white adipose tissue existing around peritoneum. Visceral adipose evokes various metabolic abnormalities such as hepatic dysfunctions, dyslipidemia, hypertension, hyperuricaemia, and impaired glucose tolerance by actively excreting free fatty acid and cytokine. The heritability of visceral obesity is partially independent from the heritability of subcutaneous fat accumulation; the identification of specifically-attributable genetic polymorphism hasn’t progressed very much yet. Understanding of the genetic background of visceral fat accumulation may contribute to pathophysiological analysis of various chronic diseases that are lead by it. Our group collected genomic DNA and the result data of various health check items such as visceral fat area of periumbilical region, serum lipid level, and existence of fatty liver from 3013 adults who had general multiphasic health screening at Jichi Medical University Hospital and then constructed visceral adipose genome bank. In this seminar, the relationship between Tribbles Pseudokinase family gene and lifestyle diseases which were revealed from the analysis of this genome bank and outcomes so far found are introduced.

・Organizer: Kazuharu Misawa, Masao Nagasaki