{"id":5067,"date":"2021-04-09T10:43:51","date_gmt":"2021-04-09T01:43:51","guid":{"rendered":"http:\/\/nagasakilab.csml.org\/ja\/?p=5067"},"modified":"2023-12-08T09:40:42","modified_gmt":"2023-12-08T00:40:42","slug":"%e5%8e%9f%e7%99%ba%e6%80%a7%e8%83%86%e6%b1%81%e6%80%a7%e8%83%86%e7%ae%a1%e7%82%8e%e3%81%ae%e6%96%b0%e3%81%9f%e3%81%aa%e9%81%ba%e4%bc%9d%e8%a6%81%e5%9b%a0%e3%82%92%e5%90%8c%e5%ae%9a%e2%80%95%e3%83%92","status":"publish","type":"post","link":"https:\/\/nagasakilab.csml.org\/ja\/archives\/5067","title":{"rendered":"\u539f\u767a\u6027\u80c6\u6c41\u6027\u80c6\u7ba1\u708e\u306e\u65b0\u305f\u306a\u907a\u4f1d\u8981\u56e0\u3092\u540c\u5b9a \u30fc\u30d2\u30c8\u5168\u30b2\u30ce\u30e0\u9818\u57df\u3078\u306eRHM\u6cd5\u306b\u3088\u308b\u4e16\u754c\u521d\u306e\u6210\u679c\u2015\u3010\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u3011"},"content":{"rendered":"<p>\u5f53\u7814\u7a76\u5ba4\u3067\u884c\u3063\u305f\u7814\u7a76\u304c\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u4eac\u90fd\u5927\u5b66\u5b66\u969b\u878d\u5408\u6559\u80b2\u7814\u7a76\u63a8\u9032\u30bb\u30f3\u30bf\u30fc \u30b9\u30fc\u30d1\u30fc\u30b0\u30ed\u30fc\u30d0\u30eb\u30b3\u30fc\u30b9\u533b\u5b66\u751f\u547d\u7cfb\u30e6\u30cb\u30c3\u30c8\u306e\u9577\ufa11\u6b63\u6717 \u7279\u5b9a\u6559\u6388\u3001Gervais Olivier\u7814\u7a76\u54e1\uff08\u7814\u7a76\u5f53\u6642\uff09\u3001\u56fd\u7acb\u56fd\u969b\u533b\u7642\u7814\u7a76\u30bb\u30f3\u30bf\u30fc \u30b2\u30ce\u30e0\u533b\u79d1\u5b66\u30d7\u30ed\u30b8\u30a7\u30af\u30c8 \u6238\u5c71\u30d7\u30ed\u30b8\u30a7\u30af\u30c8\u9577 \u5fb3\u6c38 \u52dd\u58eb\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u306f\u3001\u9577\u5d0e\u5927\u5b66\u5927\u5b66\u9662\u533b\u6b6f\u85ac\u7dcf\u5408\u7814\u7a76\u79d1\u6559\u6388\/\u56fd\u7acb\u75c5\u9662\u6a5f\u69cb\u9577\u5d0e\u533b\u7642\u30bb\u30f3\u30bf\u30fc\u5ba2\u54e1\u7814\u7a76\u54e1\u306e\u4e2d\u6751\u7a14\u3089\u306e\u30b0\u30eb\u30fc\u30d7\u304c\u4e16\u754c\u898f\u6a21\u3067\u81e8\u5e8a\u7814\u7a76\u3092\u9032\u3081\u3066\u3044\u308b\u3001\u539f\u767a\u6027\u80c6\u6c41\u6027\u80c6\u7ba1\u708e\uff08primary biliary cholangitis; PBC\uff09\uff08\u5408\u8a081,953\u4eba\uff09\u306e\u65e5\u672c\u4eba\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\u3068\u65e5\u672c\u4eba\u306e\u4e00\u822c\u96c6\u56e3\u306e\u5168\u30b2\u30ce\u30e0\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\uff08\u5408\u8a083,690\u4eba\uff09\u3068\u306e\u6bd4\u8f03\u3092\u884c\u3044\u307e\u3057\u305f\u3002<\/p>\n<p>\u305d\u306e\u7d50\u679c\u3001\u65e5\u672c\u4eba\u3067\u306f\u4eca\u307e\u3067\u5831\u544a\u304c\u306a\u30443\u7b87\u6240\u306e\u65b0\u898f\u9818\u57df\u3092\u542b\u3080\u3001\u5408\u8a087\u7b87\u6240\u306e\u67d3\u8272\u4f53\u4e0a\u306e\u75be\u60a3\u306b\u95a2\u308f\u308b\u5019\u88dc\u9818\u57df\u3092\u3001\u307b\u3068\u3093\u3069\u30d2\u30c8\u30b2\u30ce\u30e0\u60c5\u5831\u306b\u9069\u7528\u3055\u308c\u305f\u3053\u3068\u304c\u306a\u3044\u30dd\u30ea\u30b8\u30a7\u30cb\u30c3\u30af\u52b9\u679c\u3092\u8003\u616e\u3057\u305f\u624b\u6cd5\u3001\u9818\u57df\u5185\u907a\u4f1d\u7387\u63a8\u5b9a\u6cd5\uff08Regional Heritability Mapping\u6cd5; RHM\uff09\u306b\u3088\u308b\u3001\u30b2\u30ce\u30e0\u89e3\u6790\u304b\u3089\u540c\u5b9a\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u307e\u305f\u3001\u518d\u73fe\u6027\u3092\u78ba\u8a8d\u3059\u308b\u305f\u3081\u30013\u304b\u6240\u306e\u65b0\u898f\u67d3\u8272\u4f53\u5bfe\u8c61\u9818\u57df\u306b\u542b\u307e\u308c\u308bSNP\uff08\u4e00\u5869\u57fa\u591a\u578b\uff09\u306e\u3046\u3061\u3001\u7d71\u8a08\u91cf\u304c\u4e00\u756a\u6709\u610f\u3067\u3042\u3063\u305fSNP\u306b\u3064\u3044\u3066\u3001\u524d\u8ff0\u306e\u96c6\u56e3\u3068\u306f\u72ec\u7acb\u3057\u305fPBC\u60a3\u8005\uff08\u5408\u8a08220\u4eba\uff09\u3068\u3001\u4eac\u90fd\u5e9c\u7acb\u533b\u79d1\u5927\u5b66 \u5927\u5b66\u9662\u533b\u5b66\u7814\u7a76\u79d1 \u4e0a\u7530 \u771f\u7531\u7f8e\u7279\u4efb\u51c6\u6559\u6388\u304b\u3089\u63d0\u4f9b\u3055\u308c\u305f\u4e00\u822c\u96c6\u56e3\u306e\u5168\u30b2\u30ce\u30e0\u60c5\u5831\uff08\u5408\u8a08271\u4eba\uff09\u3068\u306e\u9593\u3067\u907a\u4f1d\u578b\u306e\u983b\u5ea6\u306b\u6709\u610f\u5dee\u304c\u3042\u308b\u304b\u89e3\u6790\u3092\u884c\u3044\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001\u65e5\u672c\u4eba\u3067\u306f\u4eca\u307e\u3067\u5831\u544a\u304c\u306a\u30443\u7b87\u6240\u306e\u907a\u4f1d\u5b50\u9818\u57df\uff08STAT4\uff08\u6ce84\uff09\u3001ULK4\uff08\u6ce85\uff09\u3001KCNH5\uff08\u6ce86\uff09\uff09 \u3044\u305a\u308c\u306b\u3064\u3044\u3066\u3082\u75be\u60a3\u306b\u95a2\u4fc2\u3059\u308b\u3053\u3068\u3092\u518d\u78ba\u8a8d\u3067\u304d\u307e\u3057\u305f\u3002<\/p>\n<p>\u3055\u3089\u306b\u3001\u3053\u308c\u30893\u304b\u6240\u306e\u907a\u4f1d\u5b50\u306e\u3046\u3061\u7279\u306b\u6d77\u5916\u3067\u3082\u5831\u544a\u4f8b\u304c\u306a\u3044ULK4\u3068KCNH5\u306b\u3064\u3044\u3066\u3001PBC\u306e\u60a3\u8005\u7531\u6765\u306e\u907a\u4f1d\u5b50\u3068\u975e\u7f79\u60a3\u7fa4\u306e\u907a\u4f1d\u5b50\u306e\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30fc\u30e0\u767a\u73fe\u91cf\u3092\u6bd4\u8f03\u307e\u3057\u305f\u3002\u305d\u306e\u7d50\u679c\u3001ULK4\u3092\u542b\u3080\u9818\u57df\u306b\u3064\u3044\u3066PBC\u7f79\u60a3\u7fa4\u3067\u767a\u73fe\u4e0a\u6607\u3057\u3066\u3044\u308b\u3053\u3068\u3092\u898b\u51fa\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>RHM\u6cd5\u3092\u30d2\u30c8\u5168\u30b2\u30ce\u30e0\u89e3\u6790\u306b\u9069\u7528\u3059\u308b\u3053\u3068\u3067\u65b0\u898f\u306e\u907a\u4f1d\u8981\u56e0\u3092\u540c\u5b9a\u3057\u305f\u3053\u3068\u3001\u72ec\u7acb\u3057\u305f\u96c6\u56e3\u3092\u7528\u3044\u3066RHM\u6cd5\u3067\u540c\u5b9a\u3055\u308c\u305f\u907a\u4f1d\u8981\u56e0\u306e\u518d\u691c\u8a3c\u3092\u3059\u308b\u4e00\u9023\u306e\u30b9\u30ad\u30fc\u30e0\u3092\u78ba\u7acb\u3057\u305f\u3053\u3068\u53cc\u65b9\u306e\u6210\u679c\u304c\u4e16\u754c\u521d\u306b\u306a\u308a\u307e\u3059\u3002\u540c\u624b\u6cd5\u306f\u3001PBC\u75be\u60a3\u4ee5\u5916\u306e\u591a\u56e0\u5b50\u75be\u60a3\u306b\u3082\u5e45\u5e83\u304f\u9069\u7528\u53ef\u80fd\u3067\u3042\u308a\u3001\u4eca\u5f8c\u3055\u307e\u3056\u307e\u306a\u75be\u60a3\u306b\u3082\u9069\u7528\u3059\u308b\u3053\u3068\u3067\u4e00\u822c\u7684\u306a\u30b2\u30ce\u30e0\u60c5\u5831\u89e3\u6790\u624b\u6cd5\u3067\u306f\u898b\u9003\u3055\u308c\u3066\u3044\u305f\u907a\u4f1d\u8981\u56e0\u3092\u65b0\u305f\u306b\u540c\u5b9a\u3067\u304d\u308b\u3068\u671f\u5f85\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p>\u672c\u7814\u7a76\u306f\u3001\u79d1\u5b66\u96d1\u8a8c\u300cEuropean Journal of Human Genetics\u300d\u30aa\u30f3\u30e9\u30a4\u30f3\u7248\uff089\u65e5\u4ed8\uff1a\u65e5\u672c\u6642\u95932021\u5e744\u67089\u65e5\uff09\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002\u2192<a href=\"https:\/\/www.nature.com\/articles\/s41431-021-00854-5\">Regional heritability mapping identifies several novel loci (STAT4, ULK4, and KCNH5) for primary biliary cholangitis in the Japanese population<\/a><\/p>\n<p>\u7814\u7a76\u306e\u30dd\u30a4\u30f3\u30c8<\/p>\n<ul>\n<li>\u65e5\u672c\u4eba\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\uff08PBC\u7f79\u60a3\u7fa4\u3068\u4e00\u822c\u96c6\u56e3\uff09\u3092\u6bd4\u8f03\u89e3\u6790\u3057\u65e5\u672c\u4eba\u306ePBC\uff08primary biliary cholangitis\uff09\u75be\u60a3\u306b\u95a2\u308f\u308b\uff13\u3064\u306e\u65b0\u898f\u907a\u4f1d\u5b50\u5019\u88dc\u9818\u57df\uff08STAT4\uff0cULK4\uff0cKCNH5\uff09\u3092\u540c\u5b9a<\/li>\n<li>\u540c\u30b2\u30ce\u30e0\u89e3\u6790\u306b\u3001\u9818\u57df\u5185\u907a\u4f1d\u7387\u63a8\u5b9a\u6cd5\uff08Regional Heritability Mapping; RHM\uff09\u6cd5\u3092\u6d3b\u7528<\/li>\n<li>\u72ec\u7acb\u3057\u305f\u65e5\u672c\u4eba\u907a\u4f1d\u5b50\u30c7\u30fc\u30bf\u30d9\u30fc\u30b9\uff08PBC\u7f79\u60a3\u7fa4\u3068\u4e00\u822c\u96c6\u56e3\uff09\u3092\u6bd4\u8f03\u89e3\u6790\u3057\uff13\u304b\u6240\u306e\u518d\u73fe\u6027\u3092\u691c\u8a3c<\/li>\n<li>PBC\u7f79\u60a3\u7fa4\u3068\u975e\u7f79\u60a3\u7fa4\u3068\u306e\u9593\u3067ULK4\u3068KCNH5\u306e\u809d\u81d3\u306b\u304a\u3051\u308b\u907a\u4f1d\u5b50\u767a\u73fe\u91cf\u3092\u6bd4\u8f03\u3057\u3001ULK4\u907a\u4f1d\u5b50\u304cPBC\u7f79\u60a3\u7fa4\u3067\u767a\u73fe\u4e0a\u6607\u3059\u308b\u3053\u3068\u3092\u78ba\u8a8d<\/li>\n<li>RHM\u6cd5\u3092\u30d2\u30c8\u5168\u30b2\u30ce\u30e0\u89e3\u6790\u306b\u9069\u7528\u3057\u65b0\u898f\u306e\u907a\u4f1d\u8981\u56e0\u3092\u540c\u5b9a\u3057\u305f\u3053\u3068\u3001\u304a\u3088\u3073\u3001\u72ec\u7acb\u3057\u305f\u96c6\u56e3\u306b\u5bfe\u3057RHM\u6cd5\u3067\u540c\u5b9a\u3055\u308c\u305f\u907a\u4f1d\u8981\u56e0\u3092\u691c\u8a3c\u3059\u308b\u4e00\u9023\u306e\u30b9\u30ad\u30fc\u30e0\u3092\u78ba\u7acb\u3057\u305f\u3053\u3068\u53cc\u65b9\u304c\u4e16\u754c\u521d<\/li>\n<li>\u4eca\u5f8c\u3001\u540c\u624b\u6cd5\u306f\u5e45\u5e83\u304f\u65b0\u898f\u306e\u907a\u4f1d\u8981\u56e0\u306e\u63a2\u7d22\u306b\u9069\u7528\u53ef\u80fd<\/li>\n<\/ul>\n<p>\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u672c\u6587\u306e\u30ea\u30f3\u30af<\/p>\n<ul>\n<li><a href=\"https:\/\/www.amed.go.jp\/news\/release_20210409-01.html\">AMED: \u56fd\u7acb\u7814\u7a76\u958b\u767a\u6cd5\u4eba\u65e5\u672c\u533b\u7642\u7814\u7a76\u958b\u767a\u6a5f\u69cb<\/a><\/li>\n<li><a href=\"http:\/\/www.ri.ncgm.go.jp\/topics\/release\/2021\/20210409.html\">\u56fd\u7acb\u56fd\u969b\u533b\u7642\u7814\u7a76\u30bb\u30f3\u30bf\u30fc<\/a><\/li>\n<li><a href=\"https:\/\/www.kyoto-u.ac.jp\/ja\/research-news\/2021-04-09-0\">\u4eac\u90fd\u5927\u5b66<\/a><\/li>\n<\/ul>\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u5f53\u7814\u7a76\u5ba4\u3067\u884c\u3063\u305f\u7814\u7a76\u304c\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002 \u4eac\u90fd\u5927\u5b66\u5b66\u969b\u878d\u5408\u6559\u80b2\u7814\u7a76\u63a8 &hellip; <a href=\"https:\/\/nagasakilab.csml.org\/ja\/archives\/5067\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,10],"tags":[],"class_list":["post-5067","post","type-post","status-publish","format-standard","hentry","category-event","category-news"],"_links":{"self":[{"href":"https:\/\/nagasakilab.csml.org\/ja\/wp-json\/wp\/v2\/posts\/5067","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nagasakilab.csml.org\/ja\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nagasakilab.csml.org\/ja\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nagasakilab.csml.org\/ja\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nagasakilab.csml.org\/ja\/wp-json\/wp\/v2\/comments?post=5067"}],"version-history":[{"count":9,"href":"https:\/\/nagasakilab.csml.org\/ja\/wp-json\/wp\/v2\/posts\/5067\/revisions"}],"predecessor-version":[{"id":5088,"href":"https:\/\/nagasakilab.csml.org\/ja\/wp-json\/wp\/v2\/posts\/5067\/revisions\/5088"}],"wp:attachment":[{"href":"https:\/\/nagasakilab.csml.org\/ja\/wp-json\/wp\/v2\/media?parent=5067"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nagasakilab.csml.org\/ja\/wp-json\/wp\/v2\/categories?post=5067"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nagasakilab.csml.org\/ja\/wp-json\/wp\/v2\/tags?post=5067"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}