{"id":5138,"date":"2021-06-28T16:30:24","date_gmt":"2021-06-28T07:30:24","guid":{"rendered":"https:\/\/nagasakilab.csml.org\/ja\/?p=5138"},"modified":"2023-12-08T09:40:26","modified_gmt":"2023-12-08T00:40:26","slug":"%e5%8e%9f%e7%99%ba%e6%80%a7%e8%83%86%e6%b1%81%e6%80%a7%e8%83%86%e7%ae%a1%e7%82%8e%e3%81%ae%e3%82%b2%e3%83%8e%e3%83%a0%e3%83%af%e3%82%a4%e3%83%89%e9%96%a2%e9%80%a3%e8%a7%a3%e6%9e%90%ef%bc%8d-%e5%9b%bd","status":"publish","type":"post","link":"https:\/\/nagasakilab.csml.org\/ja\/archives\/5138","title":{"rendered":"\u539f\u767a\u6027\u80c6\u6c41\u6027\u80c6\u7ba1\u708e\u306e\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\uff0d \u56fd\u969b\u30e1\u30bf\u89e3\u6790\u306b\u3088\u308b\u65b0\u898f\u75be\u60a3\u611f\u53d7\u6027\u907a\u4f1d\u5b50\u3068\u6cbb\u7642\u85ac\u5019\u88dc\u306e\u540c\u5b9a\uff0d\u3010\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u3011"},"content":{"rendered":"<p>\u5f53\u7814\u7a76\u5ba4\u3067\u884c\u3063\u305f\u7814\u7a76\u304c\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u9577\ufa11\u6b63\u6717 \u5b66\u969b\u878d\u5408\u6559\u80b2\u7814\u7a76\u63a8\u9032\u30bb\u30f3\u30bf\u30fc\u7279\u5b9a\u6559\u6388\u3001Gervais Olivier \u540c\u7814\u7a76\u54e1\uff08\u7814\u7a76\u5f53\u6642\uff09\u3001\u4e2d\u6751\u7a14 \u9577\u5d0e\u5927\u5b66\u6559\u6388\u3089\u306e\u7814\u7a76\u30b0\u30eb\u30fc\u30d7\uff08\u65e5\u672c\u4ebaPBC-GWAS consortium\uff09\u3068George Mells \u30a4\u30ae\u30ea\u30b9\u30fb\u30b1\u30f3\u30d6\u30ea\u30c3\u30b8\u5927\u5b66\u535a\u58eb\u306e\u30b0\u30eb\u30fc\u30d7\uff08UK-PBC consortium\uff09\u306f\u3001\u300cPBC-GWAS\u56fd\u969b\u5171\u540c\u7814\u7a76\uff08\u53c2\u52a0\u56fd\uff1a\u30a4\u30ae\u30ea\u30b9\u3001\u30a4\u30bf\u30ea\u30a2\u3001\u30ab\u30ca\u30c0\u3001\u7c73\u56fd\u3001\u4e2d\u56fd\u3001\u65e5\u672c\uff09\u300d\u306b\u767b\u9332\u3055\u308c\u305f\u539f\u767a\u6027\u80c6\u6c41\u6027\u80c6\u7ba1\u708e\uff08primary biliary cholangitis\uff1aPBC\uff09\u60a3\u8005 10,516\u75c7\u4f8b\u3068\u30b3\u30f3\u30c8\u30ed\u30fc\u30eb 20,772\u4f8b\u306e\u30b2\u30ce\u30e0\u30ef\u30a4\u30c9\u95a2\u9023\u89e3\u6790\uff08Genome Wide Association Study\uff1aGWAS\uff09\u30c7\u30fc\u30bf\u3092\u7528\u3044\u3066\u56fd\u969b\u30e1\u30bf\u89e3\u6790\u3092\u5b9f\u65bd\u3057\u3001\u65b0\u898f\u75be\u60a3\u611f\u53d7\u6027\u907a\u4f1d\u5b50\u9818\u57df21\u30f5\u6240\u3092\u542b\u3080\u8a0860\u30f6\u6240\u306ePBC\u75be\u60a3\u611f\u53d7\u6027\u907a\u4f1d\u5b50\u9818\u57df\u3092\u540c\u5b9a\u3059\u308b\u3053\u3068\u306b\u6210\u529f\u3057\u307e\u3057\u305f\u3002<\/p>\n<p>\u65b0\u305f\u306b\u540c\u5b9a\u3055\u308c\u305f21\u30f5\u6240\u306e\u75be\u60a3\u611f\u53d7\u6027\u907a\u4f1d\u5b50\u5ea7\u306e\u4e2d\u306b\u306f\u3001FCRL3\u3001INAVA\u3001PRDM1\u3001IRF7\u3001CCR6\u306a\u3069\u306e\u514d\u75ab\u53cd\u5fdc\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u3082\u3064\u907a\u4f1d\u5b50\u304c\u591a\u6570\u542b\u307e\u308c\u3066\u304a\u308a\u3001PBC\u306e\u767a\u75c7\u306b\u69d8\u3005\u306a\u514d\u75ab\u62c5\u5f53\u7d30\u80de\uff08\u6a39\u72b6\u7d30\u80de\u3001\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u3001T\u7d30\u80de\u3001B\u7d30\u80de\uff09\u306e\u6d3b\u6027\u30fb\u5206\u5316\u7d4c\u8def\u304c\u95a2\u4e0e\u3057\u3066\u3044\u308b\u3053\u3068\u304c\u3042\u3089\u305f\u3081\u3066\u793a\u3055\u308c\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u75be\u60a3\u611f\u53d7\u6027\u907a\u4f1d\u5b50\u9818\u57df\u306b\u306f\u7570\u306a\u308b\u96c6\u56e3\uff08\u4eba\u7a2e\uff09\u9593\u306b\u304a\u3044\u3066\u4e00\u81f4\u7387\u7d0470%\u3068\u3042\u308b\u7a0b\u5ea6\u306e\u76f8\u9055\u306f\u3042\u308b\u3082\u306e\u306e\u3001PBC\u767a\u75c7\u306b\u95a2\u308f\u308b\u907a\u4f1d\u5b50\u69cb\u9020\u3084\u75be\u60a3\u767a\u75c7\u7d4c\u8def\u306f\u7570\u306a\u308b\u96c6\u56e3\u9593\u3067\u5171\u901a\u3057\u3066\u304a\u308a\u3001TLR-TNF signaling\u3001JAK-STAT signaling\u7d30\u80de\u306eTFH,TH1,TH17,TREG\u7d30\u80de\u3078\u306e\u5206\u5316\u7d4c\u8def\u3084B\u7d30\u80de\u306e\u5f62\u8cea\u7d30\u80de\u3078\u306e\u5206\u5316\u7d4c\u8def\u304cPBC\u306e\u767a\u75c7\u306b\u91cd\u8981\u3067\u3042\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u308a\u307e\u3057\u305f\u3002<\/p>\n<p>\u307e\u305f\u3001\u3053\u308c\u3089\u306eGWAS\u60c5\u5831\u3092\u7528\u3044\u305fin silico drug efficacy screening\u306b\u3088\u308a\u3001\u65e2\u5b58\u306e\u85ac\u7269\u306e\u4e2d\u304b\u3089PBC\u6cbb\u7642\u3078\u306e\u518d\u5229\u7528\u304c\u671f\u5f85\u3055\u308c\u308b\u85ac\u7269\u5019\u88dc\u3068\u3057\u3066\u3001\u514d\u75ab\u7642\u6cd5\u85ac\uff08i.e. Ustekinumab\uff0cAbatacept\uff0cDenosumab\uff09\u3001\u30ec\u30c1\u30ce\u30a4\u30c9\uff08i.e. Acitretin\uff09\u3001\u30d5\u30a3\u30d6\u30e9\u30fc\u30c8\uff08i.e. bezafibrate\uff09\u306a\u3069\u304c\u540c\u5b9a\u3055\u308c\u307e\u3057\u305f\u3002\u4e00\u65b9\u3001PBC\u6cbb\u7642\u306e\u7b2c\u4e00\u9078\u629e\u85ac\u3068\u3057\u3066\u5e83\u304f\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u30a6\u30eb\u30bd\u30c7\u30aa\u30ad\u30b7\u30b3\u30fc\u30eb\u9178\u306f\u3001\u3053\u306e\u30b9\u30af\u30ea\u30fc\u30cb\u30f3\u30b0\u65b9\u6cd5\u3067\u306f\u85ac\u7269\u5019\u88dc\u3068\u3057\u3066\u306f\u9078\u629e\u3055\u308c\u305a\u3001GWAS\u306e\u7d50\u679c\u304b\u3089\u63a8\u5b9a\u3055\u308c\u308b\u4e0a\u8a18\u75be\u60a3\u767a\u75c7\u7d4c\u8def\u3068\u306f\u7570\u306a\u308b\u7d4c\u8def\u4e0a\u306e\u6a19\u7684\u306b\u4f5c\u7528\u3057\u3066\u3044\u308b\u53ef\u80fd\u6027\u304c\u793a\u5506\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\u672c\u7814\u7a76\u6210\u679c\u306f\u30012021\u5e745\u670821\u65e5\u306b\u3001\u56fd\u969b\u5b66\u8853\u8a8c\u300cJournal of Hepatology\u300d\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002\u2192<a href=\"https:\/\/www.journal-of-hepatology.eu\/article\/S0168-8278(21)00334-2\/fulltext\">An international genome-wide meta-analysis of primary biliary cholangitis: novel risk loci and candidate drugs.<\/a><\/p>\n<p>\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u672c\u6587\u306e\u30ea\u30f3\u30af<\/p>\n<ul>\n<li><a href=\"https:\/\/www.amed.go.jp\/news\/release_20210618.html\">AMED: \u56fd\u7acb\u7814\u7a76\u958b\u767a\u6cd5\u4eba\u65e5\u672c\u533b\u7642\u7814\u7a76\u958b\u767a\u6a5f\u69cb<\/a><\/li>\n<li><a href=\"http:\/\/www.ri.ncgm.go.jp\/topics\/release\/2021\/20210618.html\">\u56fd\u7acb\u56fd\u969b\u533b\u7642\u7814\u7a76\u30bb\u30f3\u30bf\u30fc<\/a><\/li>\n<li><a href=\"https:\/\/www.nagasaki-u.ac.jp\/ja\/guidance\/kouhou\/press\/file\/2021\/20210618.pdf\">\u9577\u5d0e\u5927\u5b66<\/a><\/li>\n<li><a href=\"https:\/\/www.kyoto-u.ac.jp\/ja\/research-news\/2021-06-28\">\u4eac\u90fd\u5927\u5b66<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u5f53\u7814\u7a76\u5ba4\u3067\u884c\u3063\u305f\u7814\u7a76\u304c\u30d7\u30ec\u30b9\u30ea\u30ea\u30fc\u30b9\u767a\u8868\u3055\u308c\u307e\u3057\u305f\u3002 \u9577\ufa11\u6b63\u6717 \u5b66\u969b\u878d\u5408\u6559\u80b2\u7814\u7a76 &hellip; <a href=\"https:\/\/nagasakilab.csml.org\/ja\/archives\/5138\">\u7d9a\u304d\u3092\u8aad\u3080 <span class=\"meta-nav\">&rarr;<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6,10],"tags":[],"class_list":["post-5138","post","type-post","status-publish","format-standard","hentry","category-event","category-news"],"_links":{"self":[{"href":"https:\/\/nagasakilab.csml.org\/ja\/wp-json\/wp\/v2\/posts\/5138","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nagasakilab.csml.org\/ja\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/nagasakilab.csml.org\/ja\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/nagasakilab.csml.org\/ja\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nagasakilab.csml.org\/ja\/wp-json\/wp\/v2\/comments?post=5138"}],"version-history":[{"count":5,"href":"https:\/\/nagasakilab.csml.org\/ja\/wp-json\/wp\/v2\/posts\/5138\/revisions"}],"predecessor-version":[{"id":5168,"href":"https:\/\/nagasakilab.csml.org\/ja\/wp-json\/wp\/v2\/posts\/5138\/revisions\/5168"}],"wp:attachment":[{"href":"https:\/\/nagasakilab.csml.org\/ja\/wp-json\/wp\/v2\/media?parent=5138"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/nagasakilab.csml.org\/ja\/wp-json\/wp\/v2\/categories?post=5138"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/nagasakilab.csml.org\/ja\/wp-json\/wp\/v2\/tags?post=5138"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}