The 33rd In Silico Megabank Research Seminar will be held on Friday, July 26.
This Time, we will be welcoming Dr. Kryukov Kirill, National Institute of Genetics as our lecturer, and he will be speaking on “A tool for genomic multiple sequence alignment.”

・Date/Time: July 26(Fri.) 17:00‐18:30
・Venue: Conference Room 1(2nd Floor), Tohoku Medical Megabank Organization
http://www.megabank.tohoku.ac.jp/english/info/access.html
・Title: MISHIMA – a tool for genomic multiple sequence alignment
・Lecturer: Kryukov Kirill (National Institute of Genetics )
・Abstract: MISHIMA is a multiple DNA sequence alignment method that uses heuristics for quickly finding regions of high similarity between sequences. MISHIMA operates by locating rare DNA fragments shared by multiple sequences and using them as alignment anchors. This technique allows aligning multiple bacterial genomes in short time. Here we present the improved version 2 of MISHIMA aligner. Sensitivity of the aligner has been improved by using only certain positions within the analyzed DNA words. Another improvement concerns the choice of the word length. In the original MISHIMA a fixed user-specified word length was used. Now it is chosen dynamically and automatically during the alignment process. Also MISHIMA can now better handle circular DNA sequences. The improved MISHIMA aligner has been tested on a range of bacterial and fungal genomes.

・Organizer: Masao Nagasaki