The 34h Silico Megabank Research Seminar will be held on Friday, August 2.
This Time, we will be welcoming Dr. Yosuke Kawai, Maebashi Institute of Technology as our lecturer, and he will be speaking on “Molecular Evolution of Natural Denatured Protein.”

・Date/Time: August 2(Fri.) 17:00‐18:30
・Venue: Conference Room 1(2nd Floor), Tohoku Medical Megabank Organization  http://www.megabank.tohoku.ac.jp/english/info/access.html
・Title: Molecular Evolution of Natural Denatured Protein
・Lecturer: Yosuke Kawai (Maebashi Institute of Technology)

・Abstract: There are some proteins that include an irregular region which does not form a fixed structure under a physiological condition. They are called natural denatured proteins. It is predicted that 30% or more of human proteins are natural denatured protein, and many of which are located in a nucleus and associated with transcription control and signal transduction. Some irregular region forms a fixed structure when forming a complex with other proteins, which is considered because the polypeptide chain in an irregular state recognizes the target molecule and both binding and folding occur in a conjugated manner. The molecular recognition mechanism of this natural denatured protein has been attracting attention in recent years as the different paradigm from the molecular recognition mechanism of proteins with a structure. Natural denatured protein is hardly present in a prokaryotic organism, and the molecular recognition through the irregular region is thought to be inherent to a eukaryotic organism. In addition, the amino acid sequence in the irregular region has poor keeping quality and seems to undergo molecular evolution close to neutrally. However, it is not understood as to why such a site came to play an important role in the protein-protein interaction. This presentation will especially focus on the interaction involving the irregular region and introduce findings regarding the relationship between the structure, function, and evolutionary rate of the natural denatured protein that have not been clarified so far.

・Organizer: Masao Nagasaki