“The 12th In Silico Megabank Research Seminar” will be held on Friday, September 14.

・Date/Time: September 14(Fri.) 17:00‐18:30
・Venue: Conference Room 1 (2F), Tohoku Medical Megabank Organization
・Lecturer: Itoshi Nikaido (Institute of Physical and Chemical Research )
・Title: Understanding on Characteristics of Cells – On ChIP-seq and Single-Cell RNA-seq

Abstract:
Our body comes into existence when only one cell properly differentiates into 400 kinds of cells. Fundamentally, these cells have the same genome information. In order for a cell to acquire individuality, a proper gene expression and a transcriptional network building in a cell is necessary. As embryonic stem cells (ES cells) differentiate, we have grasped how the transcriptional network would change structurally with the help of statistical modeling in terms of the time-series ChIP-seq and transfer. Moreover, since we are engaged in the development of the new protocol and the data-analysis technique of highly precise single cell RNA-seq in order to suppress the fluctuating cellular status that are said to be connected with individuality acquisition of a cell, we will update the current status of it as well.