“The 16th In Silico Megabank Research Seminar” will be held on Friday, November 2. The discussion will focus mainly on disease-related databases. So if you are interested, please don’t hesitate to attend the session.

・Date/Time: November 2(Fri.) 16:00‐18:00
・Venue: Conference Room 1 (2F), Tohoku Medical Megabank Organization
・Lecturer: Asako Koike　(Hitachi CRL)

Title: Title: An approach of sharing information about disease-related polymorphisms/mutation information in the integrated promotion program

Abstract: In order to prevent the dissipation of recently increasing disease-related polymorphisms/mutation information as well as to share the information among the researchers, our group (The University of Tokyo Hospital, National Institute of Genetics, and Hitachi CRL) has established “Human/GWAS DB (https://gwas.biosciencedbc.jp/)” and started deposition and redistribution of GWAS/NGS variation data. In these DBs, not only GWAS data or SNV of both healthy and diseased individuals but also the insertion/deficiency of the long sequence and conformation polymorphism are the targets of collection, which aim systematization of the relation between the variations and the phenotypes (disease, medical response, and virus tolerance) of the Japanese/Asians. The presentation will outline the bias caused by experimental methods/calculation methods and the characteristics of variations of every disease, and will also introduce the originally-developed sequence analysis/genetic statistics technology.