The 28th In Silico Megabank Research Seminar will be held on Friday, May 10.
This Time, we will be welcoming Mr. Yuji Yoshida, Nara Institute of Science and Technology as our lecturer, and he will be speaking on “Kinase Estimation for Neurite Elongation .”

・Date/Time: May 10(Fri.) 17:00‐18:30
・Venue: Conference Room 1(2nd Floor), Tohoku Medical Megabank Organization       http://www.megabank.tohoku.ac.jp/english/info/access.html
・Title: Kinase Estimation for Neurite Elongation
・Lecturer: Yuji Yoshida (Nara Institute of Science and Technology)

・Abstract: Kinases and their interactions play important roles in elongating a neurite of a developing neuron. If we can identify the kinases inhibiting neurite elongation, application to regenerative medicine is expected. Currently, it is possible to measure averaged neurite elongation for each of various patterns of kinase inhibition by existing kinase inhibitors. However, data mining is necessary for these measurements to identify the kinases which should be inhibited. It is also unknown which data mining technique is appropriate.

In this study, firstly we applied four standard regression algorithms such as least squares, partial least squares, support vector machines, and random forest, to experimental measurements. We found that random forest regression shows the best performance than the others. Using random forest algorithm, we estimated the kinases which should be inhibited for neurite elongation. As a result, three candidate kinases could be extracted.

・Organizer: Masao Nagasaki