講義名称：ゲノム医学 I （Genomic Medicine I）
開講年度・開講期：　2020年前期
日時：　 PandA オンデマンド
場所：　オンライン（PandA）
単位数：　4

(授業の概要・目的)This course will be focused on providing the knowledge which are necessary to understand Genomic Medicine. The topics cover from basic genetics and genomics knowledge to novel analytical ways for understanding epigenetics, transcriptomics, proteomics, and metabolomics. The course will be provided as a lecture by expert researcher of each research field.

(到達目標)- Understand the basic concepts behind Genomic Medicine
– Learn experimental and statistical ways to analyze genomics and other ‘omics data

(授業計画と内容)The course is divided into three major categories (1) Basics of genetics, (2) Next generation sequencing technology, and (3) muiltiple omics approach. Reseachers who are the experts of those topics will give lecture. Three special topics related to human disease genomics, namely, functional genomics, genomics of multigene family, and genomics of artificial intelligence will follow them.

Basics of genetics (1) “Human genome and genetic variation” Dr Toru Tezuka 7/May

Basics of genetics (2) “Mendel’s laws, Hardy-Weinberg Equilibrium, and Linkage disequilibrium” Dr Olivier Gervais 14/May

Basics of genetics (3) “Genetic relatedness and Population stratification” Prof Yoichiro Kamatani 21/May

Next generation sequencing (1) “DNA-seq technology and population level sequencing” Prof Masao Nagasaki 28/May

Special topic “Computation and genetics I” Dr Mario Foglio 4/Jun

Special topic “Computation and genetics II” Dr Mario Foglio 11/Jun

Next generation sequencing (2) “DNA-seq technology and rare disorders” Prof Koichiro Higasa 25/Jun

Next generation sequencing (3) “ChIP-seq, HiC-seq, ATAC-seq, and single cell sequence” Prof Akira Watanabe 2/Jul

Basics of genetics (4) “Genome wide association” Prof Yoichiro Kamatani 9/Jul

Special topic “Bioinformatics of Human Genetics” Prof Matthieu Bourgey 16/Jul

Omics approach (1) “Proteomics” Prof Yasushi Ishihama 30/Jul

Next generation sequencing (4) “RNA-seq technology and analysis” Dr Shuji Kawaguchi 6/Aug

Functional genomics :　Prof Shohab Youssefian 6/Aug

Omics approach (2) “Metabolomics” Prof Fumihiko Matsuda 6/Aug

“Feedback” 13/Aug

(履修要件)Student needs to have will to make use of genomics and other omics information into clinical medicine in the future.

(成績評価の方法・観点)Course presence plus final report

(教科書)使用しない

(参考書等) Human Molecular Genetics 4th Edition ISBN:9780815341499

(授業外学修（予習・復習）等)Required